be the best in the field of high-throughput
functional annotation bioinformatics
- Proved Science &
History: As one
of the pioneer works in the field of high-throughput
functional annotation bioinformatics, DAVID/EASE tools were released in 2003. Since then, series of novel bioinformatics algorithms have been continually developed and reported in peer-reviewed
papers. DAVID/EASE methods have gained
a larger number of citations by the genomics community, and were further ranked as the most frequently cited enrichment tool .
Due to such accomplishments, DAVID/EASE methods were recently collected by the prestigious journal, Nature Procols, as well as by the well-known laboratory book,
Current Protocols, respectively. According to DAVID web server log, the user volume of DAVID server is consistently in higher level every day (i.e. ~60,000 hits
from ~300 unique researchers per day; totally hundreds of millions
of hits from tens of thousands of visits during past 5 years).
- Novel Algorithms: Besides
typical gene-annotation enrichement analysis provided by most of high
throughput functional annotation tools, the DAVID Bioinformatics
also uniquely provide many novel functional annotation tools/algorithms
found in other similar works, for example, DAVID Gene Functional
Classification Tool can quickly group large gene list into
functional groups; DAVID
Functional Annotation Clustering Tool can condense
and redundant annotation terms into group to make ease of biological
interpretation; and more. Thus, investigators are able to explore the
biological meaning of interesting gene lists from different angles with
Visualization: "One picture is worth a thousand words".
The DAVID Pathway Viewer, a smart presentation technqiue of
'dynamic-gene-on-static-picture", allows users to exam the
interesting genes dynamically on well known human-drawn pathway
pictures, such as:
BioCarta Pathways, KEGG Pathways, Panther Pathways, etc.
- Long-term Continuous
Development & Improvement: The DAVID Bioinformatics are owned by NIH, U. S.
Goverment. It is NOT an "one-time deal" project and left there
forever. It is under continuous development and
improvement to primarily support the data
analysis needs for various HIV genomic
microarray studies in LIB
as part of "multi-million-dollar" worth HIV research
projects funded by the National
Institute of Allergy and
Infectious Diseases (NIAID/NIH). Therefore, we care the quality and
comprehensiveness of the DAVID Bioinformatics Resources as much as you
do. During past 4 years, the database and functionalities of DAVID
Bioinformatics have been continuously expanded with 4 versions, i.e. from
version 1.0, 2.0,
2.1, 2006 to current version 2007. As committed, many new
functionalities and data are being added every year to improve the
functional annotation power.
- World Top-Level Bioinformatics
Development Team: The dedicated DAVID Team consists
of real-life-experienced bioinformaticians,
professional programmers, and Ph.D level biologists, and most of whom
more than 5-year industiral and academic experiences in bioinformatics
prior to joining the team. The DAVID team also collabrates with world
top-level bioinformatics groups. This is the foundation that DAVID
Bioinformatics aim at world-class quality.
Help Line: Users
can ask questions, report bugs, suggest ideas through DAVID Forum, Hot
Email, and Telephones provided on the contact
page of DAVID Web
Site. The DAVID Team promises to reponse any above communications no
late than one business day in order to ensure your project moving on,
as well as to learn something from your questions.
the Best Thing in the World: If
you are academic users, everything on
DAVID Bioinformatics web site are FREE to use and to download. If you are
commerical users, all functionalities on DAVID web site are also Free to use, except downloading entire
EASE application & entire DAVID Knowledgebase. Please refer
to license page for the official terms.
on Mar. 2009